INTRODUCTION: The objective of this study was to evaluate the prevalence of self-diagnosis of malaria and other febrile illnesses in Bo, Sierra Leone.METHODS: All households in two neighboring sections of Bo were invited to participate in a cross-sectional survey.RESULTS: A total of 882 households (an 85% participation rate) that were home to 5410
Naphthalimides, particularly amonafide and 2-(2-dimethylamino)-6-thia-2-aza-benzo[def]chrysene-1,3-diones (R16), have been identified to possess anticancer activities and to induce G2-M arrest through inhibiting topoisomerase II accompanied by Chk1 degradation.The current study was designed to precisely dissect the signaling pathway(s) responsible
Introduction Endometriosis is a prevalent gynaecological condition for women of reproductive age worldwide.While endometriosis primarily involves the reproductive system, it can also infiltrate additional viscera such as the gastrointestinal tract.Patients with colorectal endometriosis can have severe symptoms that require surgical intervention.The
Amongst the chemokine signalling axes involved in cancer, chemokine CXCL12 acting on chemokine receptor CXCR4 is particularly significant since it orchestrates migration of cancer cells in a tissue-specific metastatic process.High CXCR4 tumour Clutch Pawl expression is associated with poor prognosis of lung, brain, CNS, blood and breast cancers.We
Abstract Background Most female mosquitoes are anautogenous and must blood feed on a vertebrate host to Henkei produce eggs.Prior studies show that the number of eggs females lay per clutch correlates with the volume of blood ingested and that protein is the most important macronutrient for egg formation.In contrast, how whole blood, blood fraction